Protective Role of Quercetin on Thioacetamide-Induced Renal Injury in Adult Male Albino Rats

Background: Thioacetamide (TAA) is a recognized industrial poisonous agent drastically used in animal studies for induction of hepatic necrosis, fibrosis and cirrhosis. It additionally reported to be nephrotoxic through oxidative stress. Quercetin (QE) has high antioxidant capacity via free radical scavenging, transition metal ion binding, lipid peroxidation inhibition. Aim the work: The goal this research was see if QE may help reduce negative effects thioacetamide on renal tissue by histological examination kidney. Material methods: Twenty four adult male Albino rats 7–9 weeks old around 180–200g body weight were allocated into 3 groups; Group I (n=8) receiving distilled water, II (n=8); TAA III QE. Results: Renal tissues examined under light microscope stained Harris Hematoxylin & Eosin (H&E stain), Periodiceeacid Schiff (PAS) andjMasson’srTrichrome TAA-treated groups revealed severe histopathological changes, whereas specimens obtained from QE-treated showed onlywmild changes. Immunohistochemical results corroborated these findings. Conclusion: This study demonstrated ameliorative consequences opposition TAA-induced injury rats. result might contribute development novel complementary alternative medication combating therapeutic intervention injury. KEY WORDS: Thioacetamide, renal, quercetin, albino rat histopathology.